Technical informations about Clomid

[4-Hydroxy-N-desethylclomiphene (4-OH-DE-CLO)]
Trade names : Clomid, Serophene
Other names Clomiphene; Chloramifene; Chloramiphene
Other names Clomiphene; Chloramifene; Chloramiphene

Clomid (Clomiphene Citrate), a Selective Estrogen Receptor Modulator (SERM), is similar to Nolvadex (Tamoxifen Citrate) in function. Initially popular as a fertility aid since the 1970s, Clomid stimulates ovulation, aiding in fertility. It’s also widely used by anabolic steroid users for two main purposes: to combat estrogenic side effects of steroids, such as gynecomastia, and as a Post Cycle Therapy (PCT) to stimulate suppressed testosterone production due to steroid use. PCT use is particularly beneficial for restoring natural testosterone levels after steroid cycles.

Clomid: Mechanism and Benefits

Clomiphene Citrate, known as Clomid, is a SERM primarily used as a fertility aid. It enhances gonadotropin release by opposing the negative feedback of estrogens on the Hypothalamic-Pituitary-Ovarian-Axis, increasing the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). This leads to egg release, thus enhancing the chance of conception.

Clomid also exhibits significant anti-estrogen properties. In the context of anabolic steroid use, it mitigates estrogenic side effects. Steroids can convert to estrogen via interaction with the aromatase enzyme, leading to issues like gynecomastia and water retention, which can cause high blood pressure. Clomid counters this by binding to estrogen receptors, inhibiting estrogen binding. This is particularly effective against gynecomastia as it prevents estrogen from stimulating mammary tissue. While it helps with water retention, Clomid does not actively reduce serum estrogen levels.

Post anabolic steroid use, Clomid plays a crucial role in Post Cycle Therapy (PCT). It stimulates the pituitary gland to release more LH and FSH, enhancing natural testosterone production. This is vital post-cycle as natural testosterone levels will be suppressed due to anabolic steroid use.

Effects of Clomid: A Detailed Analysis

[1]Fertility Enhancement:

Clomid, known for its role in fertility treatments, primarily assists women struggling with conception. By increasing the chances of pregnancy, it serves as a significant aid, though it’s not a guaranteed solution. Its efficacy in enhancing fertility will be further explored in the section dedicated to its administration.

[2] Anti-Estrogenic Properties in Steroid Use:

For individuals using anabolic steroids, Clomid acts effectively as an anti-estrogen, helping prevent gynecomastia. It doesn’t lower estrogen levels or stop the aromatization process but can protect by binding to estrogen receptors. Surprisingly, Clomid can be quite effective as a Selective Estrogen Receptor Modulator (SERM) if given a chance. Notably, it has a unique role in the liver, acting like estrogen, which can positively influence cholesterol levels. This aspect is particularly beneficial since anabolic steroid use often leads to unhealthy cholesterol profiles.

[3] Limitations and Alternative Therapies:

However, Clomid may not suffice for hardcore anabolic steroid users needing more robust estrogenic protection. In such cases, Aromatase Inhibitors (AI) like Arimidex (Anastrozole) or Femara (Letrozole) become necessary. These AIs are more effective in combating gynecomastia and managing water retention. While Clomid is limited in addressing water retention, dietary control can also play a crucial role in its management, especially in off-season bulking. Nonetheless, it’s worth noting that AIs can negatively impact cholesterol levels, making Clomid a preferable first choice if it effectively controls gynecomastia.

[4] Post-Cycle Therapy (PCT) and Natural Testosterone Recovery:

Post anabolic steroid use, natural testosterone production is typically suppressed, necessitating a PCT regime to stimulate natural production and shorten recovery time. Clomid is an excellent choice for PCT, often used in combination with Nolvadex and HCG (Human Chorionic Gonadotropin). Without PCT, individuals may experience extended periods of low testosterone, leading to increased cortisol levels, fat gain, and muscle and strength loss. Thus, for extended off-cycle periods, PCT is essential. However, for shorter off-cycle periods or bridging with low-dose exogenous testosterone, PCT might be unnecessary.

Side Effects of Clomid: An In-depth Review

[1] General Tolerability:

Clomid, classified as a Selective Estrogen Receptor Modulator (SERM) and an anti-estrogen, is known for its high tolerability among both men and women. While the potential for side effects exists, it’s crucial to understand that they are not guaranteed. The notion that side effects are certain with anabolic steroids or related substances is misleading. In fact, most individuals can use Clomid without experiencing adverse effects.

[2] Common and Rare Side Effects:

Despite its high tolerance, Clomid users may encounter some side effects, though they are generally rare. In the context of fertility treatments, a small number of women have reported ovarian enlargement. Other potential side effects include:

  • Headaches
  • Nausea
  • Hot flashes
  • Uterine bleeding (extremely rare)
  • Breast discomfort

[3] Visual Disturbances:

One noteworthy side effect associated with Clomid is visual disturbances, which may occur in about 1.5% of users. These disturbances often present as blurred or hazy vision. If such symptoms arise, it is advised to discontinue Clomid use and consider alternative medications. Typically, vision returns to normal once the medication is stopped. However, there have been rare instances where long-term or high-dose use led to persistent visual issues.

[4] Acne Development:

Another side effect, particularly noted during Post-Cycle Therapy (PCT), is acne. This is more likely related to the surge in natural testosterone production rather than Clomid itself. Individuals with a genetic predisposition to acne might notice an increase in breakouts, primarily on the back, shoulders, or chest.


While side effects are possible with Clomid use, they are not inevitable and often depend on individual factors like genetic predispositions and usage patterns. The medication’s high tolerability makes it a preferred choice in both fertility treatments and as part of PCT regimens for steroid users. However, awareness and monitoring of potential side effects are crucial for safe and effective use.

Administering Clomid: Guidelines and Protocols

[1] Fertility Aid Administration:

When used as a fertility aid, Clomid is typically administered at a dose of 50mg per day. The administration process involves starting the dosage five days into the menstrual cycle and continuing daily for five consecutive days. If conception does not occur, the dosage may be increased to 100mg per day. This process can be repeated for 5-6 menstrual cycles. If pregnancy is not achieved after this period, alternative fertility treatments should be explored.

[2] Usage in Anabolic Steroid Cycles:

For anabolic steroid users seeking estrogenic protection, the standard dosage of Clomid is 50mg per day throughout the steroid cycle. If this dosage is ineffective in providing the necessary protection, it’s unlikely that higher doses of Clomid will be beneficial. In such cases, users might find more success with the SERM Nolvadex or may require an Aromatase Inhibitor (AI) like Arimidex.

[3]  Post-Cycle Therapy (PCT):

In the context of PCT, Clomid is used to stimulate natural testosterone production following anabolic steroid use. Standard PCT dosages of Clomid usually begin at 100-150mg per day for 1-2 weeks, then decrease to 50-100mg per day for the following 1-2 weeks, and finally, 50mg per day for the last 1-2 weeks. The total duration of Clomid therapy should be between 4-6 weeks. For optimal recovery, it’s often recommended to include Nolvadex and HCG in the PCT regimen.

[4] Timing Considerations for Clomid PCT:

The timing of Clomid administration in PCT depends on the types of steroids used:

  • If the steroid cycle ends with large ester base anabolic steroids, start Clomid 2 weeks after the last injection.
  • If the cycle concludes with small ester base anabolic steroids, begin Clomid 3 days after the last injection.
  • If using HCG, start it ten days after the last injection for cycles with large ester steroids and 3 days after for cycles with small ester steroids. Clomid should begin after completing HCG therapy.
  • These guidelines ensure that Clomid is used effectively for both fertility purposes and as part of PCT in anabolic steroid cycles. Proper dosage and timing are crucial for maximizing the benefits and minimizing potential risks associated with its use.

Clomid Reviews: Evaluating Its Efficacy as a SERM

[1] Debate Among Users:

Clomid has been a subject of debate in the anabolic steroid community, particularly when compared to Nolvadex, another popular Selective Estrogen Receptor Modulator (SERM). Both have their advocates and are used for similar purposes, leading to discussions about their relative effectiveness.

[2]  Effectiveness for Gynecomastia Protection:

In terms of providing protection against gynecomastia during steroid cycles, both Clomid and Nolvadex are considered effective. Some users report that Nolvadex may be more effective, but individual responses can vary, suggesting that some may need to try both to determine which works best for their needs.

[3]  Post-Cycle Therapy (PCT) Usage:

For PCT purposes, Clomid and Nolvadex are both deemed effective and important. The debate often centers on their comparative efficacy, with some users favoring Nolvadex. However, this comparison may not always be fair, particularly if Clomid is not dosed correctly. On a milligram-for-milligram basis, Nolvadex is stronger. Therefore, if Clomid doses are not adequately adjusted to match those of Nolvadex, users may find Clomid less effective.

[4] Importance of Proper Dosing:

The key to maximizing the effectiveness of Clomid, as with any SERM, lies in understanding proper dosing protocols. Users who are well-informed about the dosing requirements and characteristics of Clomid are more likely to experience its full benefits.

[5] Conclusion:

While both Clomid and Nolvadex are effective SERMs used in the context of anabolic steroid cycles and PCT, individual preferences and responses can vary. The effectiveness of Clomid, particularly in comparison with Nolvadex, largely depends on appropriate dosing. Users should educate themselves about these medications to ensure optimal usage and results.